paklab

2015

*Rozeboom AM, *Queenan BN, Partridge JG, Farnham C, Wu JY, Vicini S, and Pak DTS. (2015) Evidence for glycinergic GluN1/GluN3 NMDA receptors in hippocampal metaplasticity. Neurobiology of Learning and Memory, 125:265-273.
*Equal contribution.

Queenan BN, Lee KJ, Tan H, Huganir RL, Vicini S, and Pak DTS. (2015) Mapping homeostatic synaptic plasticity using cable properties of dendrites. Neuroscience, in press.

2014

Lee KJ*, Rhyu IJ*, and Pak DTS*. (2014) Synapses need coordination to learn motor skills. Reviews in the Neurosciences, 25:223-30. Review.
*Co-corresponding authors.

2013

Song JM, DiBattista AM, Yang J, Pak DTS, Lee H-K, and Hoe H-S. (2013) A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer’s disease. Exp. Neurol., 252:105-113.

Sohn YI, Lee NJ, Chung A, Saavedra JM, Turner RS, Pak DTS*, and Hoe H-S*. (2013) Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochem. Biophys. Res. Comm., 439:464-470.
*Co-corresponding authors.

Queenan BN and Pak DTS. (2013) Homeostatic synaptic plasticity in the hippocampus: Therapeutic prospects for seizure control? Future Neurology, 8:361-363. Review.

Lee KJ, Park IS, Kim H, Greenough WT, Pak DTS*, and Rhyu IJ*. (2013) Motor skill training induces coordinated strengthening and weakening between neighboring synapses. J. Neurosci. 33:9794–9799. Brief Communication.
*Co-corresponding authors.

Megill A, DiBattista AM, Song JM, Spitzer M, Rubinshtein M, Habib LK, Christina C Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee H-K, and Hoe H-S. (2013) A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras mediated spinogenesis. J. Neurosci. 33:9306-9318.

*Lee KJ, *Queenan BN, Rozeboom AM, Bellmore R, Lim ST, Vicini S, and Pak DTS. (2013) Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons. Neuron 77:99–114. PMCID: in process.
*Equal contribution.
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2012

Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DTS, Sheng M, and Lee SH. (2012) GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic synaptic scaling. Nat. Neurosci. 15:1655–1666. PMCID: in process.

Queenan BN, Lee KJ, and Pak DTS. (2012) Wherefore art thou, Homeo(stasis)? Functional diversity in homeostatic synaptic plasticity. Neural Plasticity. Article ID 718203. PMCID: in process. Review.

Dumanis SB, Chamberlain KA, Sohn YJ, Lee YJ, Guénette SY, Suzuki T, Mathews PM, Pak DTS, Rebeck GW, Suh Y-H, Park H-S, and Hoe H-S. (2012) FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol. Neurodegener. 7:9. PMCID: in process.

Rozeboom AM and Pak DTS. (2012) Identification and functional characterization of Polo-like kinase 2 autoregulatory sites. Neuroscience 202:147-57. PMCID: PMC3268898.

Hoe HS, Lee HK, Pak DT. (2012) The Upside of APP at Synapses. CNS Neurosci. Ther. 18:47-56. PMCID: PMC3116065. Review.

2011

Babus LW, Little EM, Keenoy KE, Minami SS, Chen E, Song JM, Caviness J, Koo SY, Pak DT, Rebeck GW, Turner RS, Hoe HS. (2011) Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res. 1415:96-102. PMCID: in process.

Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P, Rebeck GW, Hoe HS, Weeber EJ. (2011) Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem. 18:558-64. PMCID: PMC3166788.

Lee KJ, Hoe HS, Pak DT. (2011) Plk2 Raps up Ras to subdue synapses. Small GTPases. 2:162-166 (2011). PMCID: PMC3136947. Review.

Lee KJ, Lee Y, Rozeboom AM, Lee J-Y, Udagawa N, Hoe H-S, and Pak DTS. (2011) Requirement for Plk2 in orchestrated Ras and Rap signaling, homeostatic structural plasticity and memory. Neuron 69:957-73. PMCID: PMC3073828.

Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. (2011) ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One 6:e17203. PMCID: PMC3039666.

2010

Evers DM, Matta J, Hoe H-S, Zarkowsky D, Lee SH, Isaac JT and Pak DTS. (2010) Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nat. Neurosci. 13:1199-207. PMCID: PMC2947592.

Lee KJ, Moussa CE-H, Lee Y, Sung Y, Howell BW, Lee H-K, Pak DTS*, and Hoe H-S*. (2010) Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. Neuroscience 169:344-56. PMCID: PMC2900520.
*Co-corresponding authors.

Hoe H-S and Pak DTS. (2010) Need dendritic spines? There’s an APP for that. Cognitive Sciences 5:21-34. (Review).

Minami SS, Cordova A, Cirrito J, Tesoriero JA, Babus LW, Davis GC, Dakshanamurthy S, Turner RS, Pak DTS, Rebeck GW, Paige M, and Hoe H-S. (2010) ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Mol. Neurodegener. 5:16. PMCID: PMC2890633.

*Herrick S, *Evers DM, Lee J-Y, Udagawa N, and Pak DTS. (2010) Postsynaptic PDLIM5 / Enigma Homolog binds SPAR and causes dendritic spine shrinkage. Mol. Cell. Neurosci. 43:188-200. PMCID: PMC2818455.
*Equal contribution.

Minami SS, Sung YM, Dumanis SB, Chi SH, Burns MP, Ann E-J, Suzuki T, Turner RS, Park H-S, Pak DTS, Rebeck GW, Hoe H-S. (2010) The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement. FASEB J. 24:58-69. PMCID: PMC2797038.

2009

Lu XJ, Chen XQ, Weng J, Zhang HY, Pak DT, Luo JH, and Du JZ. (2009) Hippocampal spine-associated Rap-specific GTPase-activating protein induces enhancement of learning and memory in postnatally hypoxia-exposed mice. Neuroscience 162:404-14. PMCID: PMC3243647.

*Hoe HS, *Lee KJ, Carney RSE, Lee JY, Markova A, Chakrabarti L, Lee J-Y, Howell B, Hyman BT, Pak DTS, Bu G, and Rebeck GW. (2009) Interaction of Reelin with APP promotes neurite outgrowth. J. Neurosci. 29:7459-73. PMCID: PMC2759694.
*Equal contribution.

Hoe HS, Lee JY, and Pak DTS. (2009) Combinatorial morphogenesis of dendritic spines and filopodia by SPAR and alpha-actinin2. Biochem. Biophys. Res. Commun. 384:55-60. PMCID: PMC2707853.

Hoe HS, Fu Z, Makarova A, Lee J.-Y, Lu C, Feng L, Pajoohesh-Ganji A, Matsuoka Y, Hyman BT, Ehlers MD, Vicini S, Pak DTS, and Rebeck GW. (2009) The effects of amyloid precursor protein on postsynaptic composition and activity. J. Biol. Chem. 284:8495-506. PMCID: PMC2659208.

2003-2008

Cartagena CM, Ahmed F, Pajoohesh-Ganji A, Pak DT, Faden AI, and Rebeck GW. (2008) Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J. Neurotrauma 25:1087-98. PMCID: PMC2745316.

Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DTS, and Sheng, M. (2008) Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron 58: 571-83. PMCID: PMC2488274.

Hoe HS, Cooper M, Burns MP, Lewis PA, van der Brug M, Geetanjali C, Cartagena C, Pak DTS, Cookson MR, and Rebeck GW. (2007) The metalloprotease inhibitor TIMP-3 regulates APP and ApoE receptor proteolysis. J. Neurosci. 27:10895-905.

Richter M, Murai KK, Bourgin C, Pak DT, and Pasquale EB. (2007) The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J. Neurosci. 27:14205-15.

Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, and Pak DTS. (2007) Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. J. Neurochem. 100: 118-31.

*Zhu Y, *Pak D, Qin Y, McCormack SG, Kim MJ, Baumgart JP, Velamoor V, Osten P, van Aelst L, Sheng M, and Zhu JJ. (2005) Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron 46: 905-16.
*Equal contribution.

Seeburg DP, Pak D, Sheng M. (2005) Polo-like kinases in the nervous system. Oncogene 24:292-98. (Review).

Dunah AW, Hueske E, Wyszynski M, Hoogenraad CC, Jaworski J, Pak DT, Simonetta, A., Liu, G., and Sheng, M. (2005) LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. Nat. Neurosci. 8:458-67.

Pak DTS and Sheng M. (2003) Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 302:1368-73.
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prior to 2003

Pak DTS, Yang S, Rudolph-Correia S, Kim E, and Sheng M. (2001) Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31:289-303.
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Lou J, Marzari R, Verzilo V, Ferrero F, Pak D, Sheng M, Yang C, Sblattero D, and Bradbury A. (2001) Antibodies in haystacks: how selection strategy influences the outcome of selection from molecular diversity libraries. J. Immunol. Methods 253:233-42.

Sheng M and Pak DTS. (2000) Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu. Rev. Physiol. 62:755-78. Review.

Sheng M and Pak DT. (1999) Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses. Ann. N.Y. Acad. Sci. 868:483-93.

Huang DW, Pak DTS, Botchan MR, and Kellum R. (1998) Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: their phosphorylation levels and associations with origin recognition complex proteins. J. Cell Biol. 142:307-18.

Pak DTS, Pflumm M, Chesnokov I, Huang DW, Kellum R, Marr J, Romanowski P, and Botchan MR. (1997) Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell 91:311-323.

*Gossen M, *Pak DTS, Hansen SK, Acharya JK, and Botchan MR. (1995) A Drosophila homolog of the yeast origin recognition complex. Science 270:1674-1677.
*Equal contribution.
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Ehrenhofer-Murray AE, Gossen M, Pak DTS, Botchan MR, and Rine J. (1995) Separation of origin recognition complex functions by cross-species complementation. Science 270:1671-1674.
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Lentz MR, Pak D, Mohr I, and Botchan MR. (1993) The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site. J. Virol. 67:1414-23.

Funk WD, Pak DT, Karas RH, Wright WE, and Shay JW. (1992) A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol. 12:2866-71.