Molecular Mechanisms of Synaptic Plasticity

The Pak Lab focuses on experience-dependent remodeling of the brain. We are in the Department of Pharmacology and Physiology at Georgetown University. We are interested in these research areas:

  • 1) Mechanisms underlying learning and memory.
  • 2) Homeostatic regulation of neuronal activity.
  • 3) Cognitive dysfunction in neurodegenerative disease.
  • 4) Synaptic tagging and AMPA receptor trafficking.
  • 5) Metaplasticity of NMDA receptors.

Latest Paper!

May 3, 2013

Lee KJ, Park IS, Kim H, Greenough WT, Pak DTS*, and Rhyu IJ*. (2013) Motor skill training induces coordinated strengthening and weakening between neighboring synapses. J. Neurosci. (Brief Communication), in press. *Co-corresponding authors.

Welcome to new students

May 24, 2013

Undergraduates Ray Dunn and Ryan Felix join the lab for the summer.


May 15, 2013

Ryan Bellmore finishes his undergraduate honors thesis.

In the news

January 10, 2013

Pilot Grant

July 7, 2012

GUMC Dean's Pilot Project Grant is awarded!

New students

June 20, 2012

Kelsey Cobourn, Yoon Kyu Lee, Sea On Lee, and Ji Soo Lee join the lab.

Fellowships awarded

June 20, 2012

Bridget Queenan's NRSA is funded! Ryan Bellmore is awarded a second summer GUROP fellowship!

Website launched!

June 8, 2012

Website is finally up and running!